Broad leisure network
Allegiant reaches the most nonstop destinations from Knoxville, especially vacation markets and secondary airports.
Airlines at TYS
Airlines flying from Knoxville
Start with the airline, then see every current nonstop destination and search live flights for your dates.
The short answer
6 airlines are represented on the current TYS nonstop route list.
Each airline below has its own Knoxville route page.
How the airlines differ at TYS
Hub connectivity
American, Delta and United concentrate their nonstop networks on major hubs that also open one-stop access to hundreds of onward cities.
Point-to-point alternatives
Southwest and Avelo add useful nonstop choices that can change the best airport, schedule or total trip cost.
Allegiant Air
20 current nonstop airport routes from TYS.
American Airlines
6 current nonstop airport routes from TYS.
Southwest Airlines
6 current nonstop airport routes from TYS.
Delta Air Lines
4 current nonstop airport routes from TYS.
United Airlines
4 current nonstop airport routes from TYS.
Avelo Airlines
1 current nonstop airport route from TYS.
Keep exploring Knoxville flights
Route information last checked: 2026-10-28. Current nonstop-route status is based onMcGhee Tyson Airport's official nonstop destination list. Individual airline schedules can change.See how we verify flight information →