Seasonal nonstop flights from Knoxville

• Austin AUS Allegiant and Southwest · flies Mondays, Wednesdays, Fridays and Sundays · about 2 hr 35 minNext flight: Fri, Oct 30 at 8:30 am
• Boston BOS Allegiant · flies every day except Friday · about 2 hr 15 minNext flight: Thu, Oct 29 at 7:30 am
• Destin / Fort Walton Beach VPS Allegiant · flies Tuesdays, Thursdays, Saturdays and Sundays · about 1 hr 25 minNext flight: Thu, Oct 29 at 2:01 pm
• Fort Lauderdale FLL Allegiant · flies every day · about 2 hr 5 minNext flight: Thu, Oct 29 at 9:05 am
• Gulf Shores / Orange Beach GUF Starts May 6AllegiantFlights for sale from May 6, 2027
• Jacksonville JAX Allegiant · flies Tuesdays, Thursdays, Saturdays and Sundays · about 1 hr 20 minNext flight: Thu, Oct 29 at 6:24 pm
• Key West EYW Allegiant · flies Mondays, Wednesdays, Fridays and Sundays · about 2 hr 5 minNext flight: Fri, Oct 30 at 7:00 am
• Memphis MEM Allegiant · flies Fridays and Sundays · about 1 hr 20 minNext flight: Fri, Nov 6 at 6:47 pm
• New Orleans MSY American and Southwest · flies Sundays · about 2 hrNext flight: Sun, Nov 22 at 11:20 am
• Phoenix PHX Allegiant · flies Mondays, Tuesdays, Thursdays, Saturdays and Sundays · about 4 hr 10 minNext flight: Thu, Oct 29 at 1:52 pm
• Punta Gorda PGD Allegiant · flies every day · about 1 hr 55 minNext flight: Fri, Oct 30 at 8:40 pm
• Sarasota / Bradenton SRQ Allegiant · flies Mondays, Wednesdays, Thursdays, Fridays and Sundays · about 1 hr 50 minNext flight: Thu, Oct 29 at 12:19 pm

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Flight days and times last checked Wednesday, October 28, 2026 using Google Flights. We check every week. The list of nonstop destinations comes from McGhee Tyson Airport's official nonstop list (checked October 26, 2026).Schedules can change, so always confirm your exact flight with the airline. How we check flights.