Year-round nonstop flights from Knoxville

• Atlanta ATL Delta · flies every day · about 1 hr 5 minNext flight: Thu, Oct 29 at 5:40 am
• Charlotte CLT American · flies every day · about 1 hr 25 minNext flight: Thu, Oct 29 at 6:56 am
• Chicago ORD / MDW American, United and Allegiant · flies every day · about 1 hr 35 minNext flight: Thu, Oct 29 at 6:45 am
• Dallas DFW / DAL American and Southwest · flies every day · about 2 hr 30 minNext flight: Thu, Oct 29 at 6:00 am
• Denver DEN Allegiant, Southwest and United · flies every day · about 3 hr 25 minNext flight: Thu, Oct 29 at 6:30 am
• Detroit DTW Delta · flies every day · about 1 hr 45 minNext flight: Thu, Oct 29 at 7:26 am
• Houston IAH / HOU United and Allegiant · flies every day · about 2 hr 20 minNext flight: Thu, Oct 29 at 7:00 am
• Miami MIA American · flies every day · about 2 hr 15 minNext flight: Thu, Oct 29 at 6:00 am
• Minneapolis / St. Paul MSP Delta · flies every day · about 2 hr 35 minNext flight: Thu, Oct 29 at 8:09 am
• New York LGA / EWR American, Delta, Allegiant and United · flies every day · about 2 hrNext flight: Thu, Oct 29 at 6:00 am
• Philadelphia PHL Allegiant and American · flies every day · about 1 hr 55 minNext flight: Thu, Oct 29 at 6:00 am
• Washington, DC DCA / IAD American, Allegiant and United · flies every day · about 1 hr 45 minNext flight: Thu, Oct 29 at 5:45 am

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Flight days and times last checked Wednesday, October 28, 2026 using Google Flights. We check every week. The list of nonstop destinations comes from McGhee Tyson Airport's official nonstop list (checked October 26, 2026).Schedules can change, so always confirm your exact flight with the airline. How we check flights.